While IL-17 was the only one significantly increased, several other inflammatory factors attracting and activating eosinophils (i.e., RANTES, IFN-γ, IL-4, IL-13, GM-CSF, and IL-5) showed a trend toward enrichment in the BM sera of SMM patients rapidly progressing to MM (Supplementary Fig. 7 ).
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Microbiota-driven interleukin-17-producing cells and eosinophils synergize to accelerate multiple myeloma progression.
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