Antibody-Based In Vivo PET Imaging Detects Amyloid-β Reduction in Alzheimer Transgenic Mice After BACE-1 Inhibition.

J Nucl Med · 2018 · PMC6278900 · PMID 29853653

Europe PMC DOI

hedged sentence

0.0510

closest p · 1.0× alpha

0.0510

boldest claim

The sentences

nearly significantP = 0.051so close (0.05 < p ≤ 0.1)

A ratio of soluble Aβ aggregates over total soluble Aβ displayed a nearly significant difference ( P = 0.051) between the baseline group (1.9 ± 1.4) and the NB-360 group (0.8 ± 0.5), indicating a relative decrease in Aβ oligomerization as a result of BACE-1 inhibition.

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