Hepatic gene body hypermethylation is a shared epigenetic signature of murine longevity.

PLoS Genet · 2018 · PMC6281273 · PMID 30462643

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a significant trendno p-value reported

For the group of differentially expressed and hypermethylated genes above the minimum methylation cut-off, we ran a binomial test to probe for a significant trend towards down- or up-regulation.

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highly significantno p-value reported

Given that the global methylome remained unchanged, these overlaps were highly significant (each: p < e -16 , Fisher’s exact test), strongly indicating that their co-occurrence was not due to chance.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.