Dietary Macronutrient Composition Determines the Contribution of DGAT1 to Alcoholic Steatosis.

Dgat1 −/− mice consuming a low‐fat diet, like WT mice, had a highly significant increase in hepatic TG concentration with alcohol consumption (Fig. 5 A ).

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In terms of fibrosis markers, there were no significant effects on the expression of Col1a1 or Acta2 , although both showed a trend for increased expression in the alcohol‐fed mice on a high‐fat diet.

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