Noncanonical farnesoid X receptor signaling inhibits apoptosis and impedes liver fibrosis.

EBioMedicine · 2018 · PMC6286639 · PMID 30337250

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Immunohistochemical staining of fibrotic livers indicated a clear trend of gradual loss of cytoplasmic FXR from stage-1 to stage-4 liver fibrosis ( Fig. 7 D), and also the decreased co-localization of FXR with CASP8 in the cytoplasm ( Fig. 7 E).

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