Multidrug-resistant tuberculosis (MDR-TB) strain infection in macaques results in high bacilli burdens in airways, driving broad innate/adaptive immune responses.

We found that although the increased production of caspase 3 by blood monocytes did not reach statistical significance (Fig. 2a ), by week 3, the number of caspase 3+ CD14+ macrophages in the BALF of MDR-Mtb-infected macaques was significantly greater than the number in the BALF from Erdman strain-infected animals (Fig. 2b ).

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