Corticosteroid use and increased CXCR2 levels on leukocytes are associated with lumacaftor/ivacaftor discontinuation in cystic fibrosis patients homozygous for the F508del CFTR mutation.

Differences in ppFEV 1 and ppFEF 25-75 , and the proportion of patients with severe lung disease (ppFEV 1 ≤ 40%) or a potential indication of small airway disease (ppFEF 25-75 ≤ 60%) [ 28 ] did not reach statistical significance between subgroups.

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