Intermittent Hypoxia Activates Duration-Dependent Protective and Injurious Mechanisms in Mouse Lung Endothelial Cells.

Front Physiol · 2018 · PMC6291480 · PMID 30574096

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The inflammatory transcription factor NFκB subunit p65 showed no change at 4 h of all conditions, showed a trend toward upregulation under all hypoxic conditions at 24 and 72 h with high variation, but the strongest and statistically significant increase was observed with 72 h of intermittent hypoxia (+33.6 ± 10.31 fold change compared to normoxia; p < 0.0001).

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