However, the cGMP synthesis induced by SNP was significantly enhanced by a 15-min preincubation with GLP-1(7–36), GLP-1(9–36) and Liraglutide, whereas cAMP levels showed a trend to increase in response to SNP+GLP-1 peptides, while not reaching statistical significance (n=6; p=NS vs basal values for each GLP-1 receptor agonist with or without SNP).
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Glucagon-like peptide 1-related peptides increase nitric oxide effects to reduce platelet activation.
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