Cholinergic Receptor Nicotinic Alpha 5 (CHRNA5) RNAi is associated with cell cycle inhibition, apoptosis, DNA damage response and drug sensitivity in breast cancer.

Comparison of the co-expression profile of CHRNA5 expression across 59 CCLE breast cancer cell lines with the logFC values from CHRNA5 RNAi profile revealed a highly significant negative correlation and association (r = -0.33, p = 3.8E-48).

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We showed that CHRNA5 was significantly reduced by siRNA-2 and the reduction approached significance with siRNA-1 ( Fig 9D ).

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