Acquired parvalbumin-selective interneuronopathy in the multiple-hit model of infantile spasms: A putative basis for the partial responsiveness to vigabatrin analogs?

Although our findings did not reach statistical significance, these trends may warrant more systematic quantitative morphometric analyses of the somata and arborization of interneurons, to confirm whether there is also disrupted connectivity and integration of the remaining PRV interneurons in the local circuits.

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