Flexibility and structure of flanking DNA impact transcription factor affinity for its core motif.

Nucleic Acids Res · 2018 · PMC6294565 · PMID 30395339

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a negative trendno p-value reported

Figure 6 depicts that binding affinity of Hox-3 TFs shows a negative trend with free energy of the 3′-flank, while it is positively correlated with propeller twist, ORChID, and minor groove width (MGW-PDB).

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