What defines an antibody as humanized or human? While the nomenclature suggested that immunogenicity of non-human antibodies could be reduced in a sequential order from murine to chimeric to humanized mAbs by increasing the fraction of ‘human sequences’, experimental data supporting this was missing, and any proof of a clear trend in reduction of immunogenicity between these humanization techniques was not always unambiguously translated into the clinics.
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Nomenclature of humanized mAbs: Early concepts, current challenges and future perspectives.
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