Association of CHFR Promoter Methylation with Treatment Outcomes of Irinotecan-Based Chemotherapy in Metastatic Colorectal Cancer.

Neoplasia · 2019 · PMC6297269 · PMID 30562637

Europe PMC DOI

hedged sentences

0.0500

closest p · 1.0× alpha

0.0500

boldest claim

The sentences

marginally significantP = .050actually significant

TTP was marginally significant favoring the WRN -methylated group ( P = .050; Supplementary material 4 ).

also in 26,082 other papers

showed a trendno p-value reported

OS showed a trend towards the CHFR- methylated group, but the difference was not significant ( P = .300; Figure 1 B ).

also in 53,322 other papers

highly significantno p-value reported

Therefore, prediction of treatment response or resistance to cytotoxic chemotherapy is a highly significant and clinically relevant issue to further improve the treatment outcomes of patients with metastatic CRC.

also in 132,142 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.