20 A 2016 randomized controlled trial by Gupta and colleagues conducted at a tertiary care center in India revealed a lower rate of culture-confirmed bacterial sepsis in neonates receiving daily chlorhexidine baths for the first seven days of life, 3.57% of neonates versus 6.85% of neonates receiving placebo; these findings did not reach statistical significance. 21 More studies are needed to study the safety, efficacy, and dosing of CHG in high-risk neonates.
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The impact of chlorhexidine gluconate bathing on skin bacterial burden of neonates admitted to the Neonatal Intensive Care Unit.
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