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Optimized vinpocetine-loaded vitamin E D-α-tocopherol polyethylene glycol 1000 succinate-alpha lipoic acid micelles as a potential transdermal drug delivery system: in vitro and ex vivo studies.

Int J Nanomedicine · 2019 · PMC6302827 · PMID 30587983

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a negative trendno p-value reported
As illustrated in Figures 3B and 4C , the percentage of ALA in TPGS (X 1 ) is the only factor that significantly affected the initial permeation after 2 hours (Y 2 ) in a negative trend with a P -value of 0.0015 ( Table 3 ).

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