Diazepam is not a direct allosteric modulator of α₁-adrenoceptors, but modulates receptor signaling by inhibiting phosphodiesterase-4.

Furthermore, the GABA A R‐inactive benzodiazepine, 7‐phenyl‐diazepam, was able to modulate the phenylephrine‐induced CRE activation, although its actions on forskolin failed to reach statistical significance (Figure 5 and Table 1 ).

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