Modular Nanoparticulate Prodrug Design Enables Efficient Treatment of Solid Tumors Using Bioorthogonal Activation.

From this analysis and an examination of the simulation results, an important trend was captured: through the combination of saturable phagocytic clearance in the liver (amplified through staggered NP administration), and compounded EPR effect in the tumor, drug activation was observed to be more selective in the tumor compared to distribution of the catalyst NP or its prodrug NP substrate ( Figure 6 d).

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