Thrombin contributes to the injury development and neurological deficit after acute subdural hemorrhage in rats only in collaboration with additional blood-derived factors.

BMC Neurosci · 2018 · PMC6307215 · PMID 30591020

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showed a trendno p-value reported

Animals treated with SCH79797 also showed a trend towards dose-dependent decreased lesion volume in comparison to the vehicle-treated group (1 μg: 4.3 ± 0.7 mm 3 ; 5 μg: 3.8 ± 1.1 mm 3 ; vehicle: 6.5 ± 2.0 mm 3 , n.s).

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a slight trendno p-value reported

The results of the volumetric lesion determination and the functional outcome both show a slight trend in favor of thrombin inhibition or PAR1 antagonism.

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