Enteropathogenic E. coli relies on collaboration between the formin mDia1 and the Arp2/3 complex for actin pedestal biogenesis and maintenance.

Quantification of the ratio of pSrc to HA-Tir intensity revealed that active SFK levels were indeed lower in the pedestal-forming regions of cells treated with mDia1 siRNAs, although data for one of the siRNAs did not reach statistical significance ( Fig 8E ).

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