Inhibition of Triggering Receptor Expressed on Myeloid Cells 1 Ameliorates Inflammation and Macrophage and Neutrophil Activation in Alcoholic Liver Disease in Mice.

Interestingly, the HDL vehicle alone also resulted in a decreasing trend of Ly6G and MPO expression in alcohol‐fed mice; however, the GF9‐HDL and GA/E31‐HDL TREM‐1 inhibitors significantly attenuated Ly6G and MPO levels even when compared to the vehicle‐treated alcohol‐fed mice (Fig. 3 E,F).

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The increase in total IL‐1ß levels after alcohol feeding and its attenuation by TREM‐1 inhibition did not reach statistical significance (Fig. 2 D).

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