Time Trends in Atrial Fibrillation-Associated Stroke and Premorbid Anticoagulation: Population-Based Study and Systematic Review.

Stroke · 2019 · PMC6314508 · PMID 30580714

Europe PMC DOI

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a clear trendno p-value reported

However, there was a clear trend of increasing incident ischemic stroke associated with prior AF from 1960s to 2000 before stabilizing thereafter.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.