CCP1 promotes mitochondrial fusion and motility to prevent Purkinje cell neuron loss in <i>pcd</i> mice.

To assess the physiological significance of Parkin-dependent degradation of CCP1, we again cultured primary granule cell neurons under conditions of mitochondrial stress but did so in the presence or absence of Parkin knockdown, and we noted that CCP1 degradation was obviously reduced upon Parkin knockdown, though the level of reduction only constituted a strong trend ( Fig. 9 E ).

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