Moderate-to-severe asthma in individuals of European ancestry: a genome-wide association study.

Both the KIAA1109 and GATA3 signals meet the threshold for independent replication based on Bonferroni correction threshold (p<0·005, Bonferroni correction for 11 potentially novel signals); however, the MUC5AC signal did not meet this threshold but was nominally significant (p=0·018; table 2 ) To identify if the novel signals for moderate-to-severe asthma were also associated with all asthma including mild disease, we checked the association results from a large independent genome-wide association study. 5 We found both the KIAA1109 and GATA3 signals were significantly associated with all asthma, including mild asthma ( KIAA1109 [proxy rs72687036 coded allele G]: OR 1·06, 95% CI 1·04–1·08; p=3·96 × 10 −7 ; and GATA3 [rs10905284, risk allele C]: OR 1·04, 1·02–1·06; p=2·72 × 10 −5 ).

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