A Wars2 Mutant Mouse Model Displays OXPHOS Deficiencies and Activation of Tissue-Specific Stress Response Pathways.

Heart-Specific Activation of the ISR Caused Increased Plasma FGF21 and Systemic Changes in Metabolism Fasted plasma FGF21 protein levels showed a trend toward elevation in male Wars2 V117L/V117L mice relative to controls at 12 months ( Figure 7 A) and similarly, but reaching significance, at 4 months of age in males only ( Figures S6 A and S6B).

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