Discoidin-domain receptor coordinates cell-matrix adhesion and collective polarity in migratory cardiopharyngeal progenitors.

Complementary loss-of-function approaches validated the specificity of the Ddr dn -induced phenotype, as lineage-specific RNAi using short hairpin microRNA (shmiR) constructs showed a trend suggesting synergy with low doses of Ddr dn to cause a penetrant de-adhesion phenotype (Supplementary Figure 4 ).

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