Modulation of Hypoxia-Induced Chemoresistance to Polymeric Micellar Cisplatin: The Effect of Ligand Modification of Micellar Carrier Versus Inhibition of the Mediators of Drug Resistance.

Under normoxic conditions, co-treatment of MDA-MB-231 cells with P1 and cisplatin formulations showed a trend towards potentiating the anticancer effect of cisplatin, plain cisplatin micelles or GE11 cisplatin micelles, as measured by MTT assay, although the difference was not statistically significant ( Figure 5 c–e, white bars).

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