Increased NEFA levels reduce blood Mg²⁺ in hypertriacylglycerolaemic states via direct binding of NEFA to Mg².

However, while the reduction in the plasma Mg 2+ concentration was numerically similar to that observed in wild-type mice, it did not reach statistical significance in Kir6.2-p.Val59Met mice due to a high variation between the animals (which was substantially larger than in the initial experiment using wild-type mice).

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