Moderate weight loss attenuates chronic endoplasmic reticulum stress and mitochondrial dysfunction in human obesity.

Finally, when we explored possible associations among variations in molecular markers and clinical metabolic outcomes after dietary weight loss intervention, we found that percentage of change of HOMA-IR was correlated significantly with that of ATF6 (r = 0.478, p = 0.018, n = 24), JNK-P (r = 0.442, p = 0.016, n = 24) and CHOP – although in this latter case it did not reach statistical significance (r = 0.371, p = 0.075, n = 24) – pointing out to a relationship between changes in IR, ER stress and proinflammatory signals.

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