Among patients who had IgG levels within the reference range before rituximab use ( Figure 2 E), an increase in the rate of severe infections was observed following rituximab use, but the difference did not reach statistical significance (from 26.0% to 30.7%; P = .20).
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Association of Immunoglobulin Levels, Infectious Risk, and Mortality With Rituximab and Hypogammaglobulinemia.
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