Inhibins regulate peripheral regulatory T cell induction through modulation of dendritic cell function.

Furthermore, we found a significant increase in the number of OT‐II + CD45.1 + FoxP3 + pTregs in Inhα −/− mice immunized with α‐DEC‐OVA compared to Inhα +/+ , while Inhα −/− mice immunized with α‐DEC‐OVA+CT showed a trend towards an increase in the number of pTregs compared to the Inhα +/+ counterparts, indicating that Inhα −/− DCs are more prone to induce a tolerogenic response in vivo even in the presence of adjuvant.

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