The novel exchange protein activated by cyclic AMP 1 (EPAC1) agonist, I942, regulates inflammatory gene expression in human umbilical vascular endothelial cells (HUVECs).

As with RNA-Seq experiments we found that treatment of HUVECs with 007 for 48 h led to a general suppression of gene expression, although the majority of changes did not reach statistical significance ( Fig. 4 c).

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