The Endothelin Receptor Antagonist Macitentan Improves Isosorbide-5-Mononitrate (ISMN) and Isosorbide Dinitrate (ISDN) Induced Endothelial Dysfunction, Oxidative Stress, and Vascular Inflammation.

Oxid Med Cell Longev · 2018 · PMC6327264 · PMID 30687454

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showed a trendno p-value reported

The mRNA expression of ECE-1 showed a trend of an increase under ISDN therapy and a complete normalization by cotherapy with macitentan ( Figure 9(b) ).

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