This observation is quite significant as we have shown that cartilage engineered de novo in skeletally mature rabbits by inducing chondrogenesis from periosteal progenitor cells is hypercellular and therefore capable of undergoing remodeling in vivo as they try to attain cellular homeostasis [ 41 ].
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Cell number in mesenchymal stem cell aggregates dictates cell stiffness and chondrogenesis.
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