Dissociable cognitive impairments in two strains of transgenic Alzheimer's disease mice revealed by a battery of object-based tests.

Paired sample t-tests between sample and choice DR suggest intact memory in Wt males and Wt females at 5 min (Wt males, 5 min: t 10 = −3.253, p = 0.009; Wt males, 3 h: t 10 = −2.787, p = 0.019; Wt females, 5 min: t 7 = −6.195, p < 0.001), but impaired memory in Wt females at 3 h (although approaching statistical significance; t 7 = 2.071, p = 0.054), and 5xFAD mice in all conditions, as they failed to discriminate between the novel and sample objects (5xFAD males, 5 min: t 9 = −2.062, p = 0.069 (although approaching significance); 5xFAD males, 3 h: t 9 = 1.009, p = 0.339; 5xFAD females, 5 min: t 10 = −0.407, p = 0.692; 5xFAD females, 3 h: t 10 = 0.870, p = 0.405). 3xTG mice, however, were impaired in a delay-dependent manner (2 × 2 × 2 split-plot ANOVA: genotype (F 1,36 = 26.260, p < 0.001), delay (F 1,36 = 19.172, p < 0.001), and genotype x delay (F 1,36 = 21.012, p < 0.001); Fig. 1g ).

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3xTG mice had intact perception (3xTG males, visual: t 13 = 3.609, p = 0.003; 3xTG males, tactile: t 13 = 5.065, p < 0.001; 3xTG females, visual: t 13 = 4.027, p = 0.001; 3xTG females, tactile t 13 = 3.788, p = 0.002), except on the MSO task (males: t 13 = 0.401, p = 0.695; females: t 13 = 2.156, p = 0.050 (although very close to significance)).

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