ncdDetect2: improved models of the site-specific mutation rate in cancer and driver detection with robust significance evaluation.

For protein-coding genes, a 53% (1.64 SD) elevation in the mutation rate will thus never be nominally significant. 3.2 Length scale of regions with biased mutation rates The neutral background mutation rate is predicted by the statistical mutation-rate model relying on a number of genomic features known to correlate with the mutation rate in cancer ( Bertl et al. , 2018 ).

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