Estrogen receptor signaling regulates the expression of the breast tumor kinase in breast cancer cells.

Although our data, in general, did not reach statistical significance, it can be deduced that high BRK expression was significantly associated with poor RFS in tamoxifen-treatment patients ( n = 161; P = 0.0043; Additional file 2 : Figure S3G), thus strengthening the rationale for ER/BRK co-targeting in ER-positive breast cancers.

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