None (lead replication SNP: rs860447, MAF = 0.26, p = 0.60, Yale-Penn/STARRS EA-EA meta p = 6.4 × 10 −3 ) replicated in the STARRS EA data, but 34 of the top 98 EA SNPs were nominally significant in the STARRS LAT samples, and, remarkably, all 98 had effect direction consistent with what we observed in Yale-Penn EAs; the lead SNP from Yale-Penn EAs was nominally significant in STARRS LATs (rs1677091, MAF = 0.28 p = 6.52 × 10 −3 ) and improved in a meta-analysis of the Yale-Penn EA and STARRS LAT samples (meta p = 4.7 × 10 −9 ).
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Genetic associations with suicide attempt severity and genetic overlap with major depression.
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