Parent-of-origin effects on quantitative phenotypes in a large Hutterite pedigree.

Although none of the parent-of-origin eQTLs met criteria for significance after correcting for multiple testing, the SNP on chromosome 9 with opposite POEs on total cholesterol levels was borderline significant as an opposite parent-of-origin eQTL for POLR1E , and possible for three other genes at the same locus ( PAX5 , FBXO10 , and FRMPD1 ).

also in 11,409 other papers

Exactly how much loci with POEs in humans contribute to phenotypic variation and disease risk overall remains to be determined, but our study provides compelling evidence that it is likely to be significant for many important traits.

also in 1,824 other papers

Of the remaining eight single parent associations with six phenotypes (SBP, age of menarche, LDL-C, Total cholesterol, CIMT, FEV 1 ), only one SNP with FEV 1 was nominally significant ( p -value 0.0391; replication p -value threshold 0.003125 for 16 tests) in the Sardinians.

also in 7,732 other papers