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Bisphenol A Exposure and Sperm ACHE Hydroxymethylation in Men.

Int J Environ Res Public Health · 2019 · PMC6339044 · PMID 30626059

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In a linear regression analysis adjusted for confounders, a positive linear association between urine BPA concentration and 5-hydroxymethylcytosine (5hmC) rate of the sperm ACHE gene was observed, although the association did not reach statistical significance in all categories after being stratified by the BPA tertile.

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The linear regression analysis using the continuous BPA level found that increasing BPA was associated with increased 5hmC, but the association was marginally statistically significant (β = 0.046, 95%CI: 0.000, 0.0092).

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