Real world scenarios in rare variant association analysis: the impact of imbalance and sample size on the power in silico.

BMC Bioinformatics · 2019 · PMC6343276 · PMID 30669967

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a clear trendno p-value reported

Based on our type I error and power results across various unbalanced sample sizes, a clear trend exists between these statistics and the number of cases in addition to the case to control ratio (simulation results of constant case to control ratio are shown in Additional file 1 : Figure S3).

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