Antipsychotic augmentation in the treatment of obsessive-compulsive disorder.

A small RCT of quetiapine augmentation in highly SSRI-resistant OCD patients found that quetiapine (mean dose of 215 mg/day) was numerically superior to placebo; however, the difference did not reach statistical significance.[ 27 ] Another placebo-controlled RCT with quetiapine augmentation of up to 400 mg/day in OCD patients unresponsive to SSRIs failed to demonstrate any efficacy.[ 28 ] META-ANALYSES There are 15 RCTs till date on antipsychotic augmentation in treatment-resistant OCD.

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However, there was a numerical trend favoring paliperidone, and the authors suggested a better-powered RCT to conclusively address the issue of efficacy.[ 15 ] Aripiprazole Aripiprazole is another well-studied antipsychotic augmenting agent for the treatment of OCD in both youth and adults.

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