DNA mapping and kinetic modeling of the HrdB regulon in Streptomyces coelicolor.

When analyzing the function of this group of genes, we found that the enrichment within the group was found for the ‘chromosomal replication’ group (just one gene SCO2064 DNA polymerase III subunit alpha of total eight genes), ‘adaptation’ (just 4 genes of 43, including two cold-shock proteins SCO3731 and SCO4505), ‘energy metabolism’ (3.2× more abundant with 25 genes of 189 total, comprising complete subunits of NADH dehydrogenase), ‘nucleotide biosynthesis’ (3.2×, 4 of 30 total, probably not significant); the group ‘ribosome constituents’ (13.8×, 38 of 67 total, including majority of ribosomal proteins) seems to be most important.

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