borderline significanceP = 0.31
When the six trials [ 27 , 48 , 49 , 51 – 53 ] that compared CHM with antidepressants were analyzed, the results showed borderline significance (RR 1.08, 95% CI 0.93 to 1.26; P = 0.31) with little heterogeneity (I 2 = 18%, P = 0.30), although a tendency towards a superior effect was noted in the CHM group.