Bacterial regulation of macrophage bacterial recognition receptors in COPD are differentially modified by budesonide and fluticasone propionate.

The pattern of baseline scavenger receptor expression that we observed in subjects with COPD and Sm were consistent with a mixed M1 (increased SR-AI expression) and M2 phenotype (increased MARCO and reduction in SR-AI), with statistically significant increases in expression of both SR-AI and MARCO in Sm and COPD-S as compared to NoS, and only MARCO in COPD-ES (though SR-AI is still elevated in COPD-ES above NoS, this difference did not reach statistical significance).

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