Enhanced activity of pyramidal neurons in the infralimbic cortex drives anxiety behavior.

Again we found a highly significant increase of total c-fos in fearful situation in Wt, as well as in 5-HT 1A (-/-) mice (Wt naïve 11.64±0.45, 1A-ko naïve 32.74±1.45, p≤0.001, Wt anxiety 179.9±4.6, 1A-ko anxiety 211.33±5.36, p≤0.001.) ( Fig 2A–2D ).

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Just like in the EPM also the NSF confirmed enhanced anxiety in 5-HT 1A (-/-) knockout mice, time spent in the center of the arena (Wt = 27.32±3.81s, 1A-ko = 17.57±2.6s, p = 0.042) is significantly decreased and time till feeding showed a trend towards longer waiting times (Wt 118.56±19.16s, 1A-ko 146.69±36.67s, p = 0.772) ( S1F and S1G Fig ).

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