Mutual action by Gγ and Gβ for optimal activation of GIRK channels in a channel subunit-specific manner.

When GIRK1* Δ121 was expressed at a higher level, 2 ng RNA, WT Gγ did not enhance I basal , but YFP-Gγ appeared to produce a residual 2-fold activation of GIRK1* Δ121 that did not reach statistical significance in one-way ANOVA test (Supplementary Fig.

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