Spatial patterns of white matter hyperintensities associated with Alzheimer's disease risk factors in a cognitively healthy middle-aged cohort.

Alzheimers Res Ther · 2019 · PMC6346579 · PMID 30678723

Europe PMC DOI

hedged sentences

0.0530

closest p · 1.1× alpha

0.0530

boldest claim

The sentences

showed a trendp = 0.053so close (0.05 < p ≤ 0.1)

Hypercholesterolemia also displayed a significant effect (effect size 0.09, 95% CI 0.00–0.17, p = 0.042) and BMI showed a trend to significance (effect size 0.08, 95% CI −0.00 to 0.16, p = 0.053).

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did not achieve significanceno p-value reported

However, the APOE-ε2/ε3 group was significantly younger than the reference group (56 vs 60 years old; p < 0.001, Additional file 1 : Table S7) and, when corrected by age (Model 2), this comparison did not achieve significance.

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