Host genetic variants in sepsis risk: a field synopsis and meta-analysis.

Crit Care · 2019 · PMC6347778 · PMID 30683156

Europe PMC DOI

hedged sentences

0.0010

closest p · 0.0× alpha

0.0500

boldest claim

The sentences

highly significantp < 0.001actually significant

Ten of the 29 positive variants showed a highly significant association with sepsis risk, with p < 0.001; 11 showed an association with sepsis risk with p = 0.001–0.01, and the remaining 8 had p < 0.05.

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nominally significantP < 0.05actually significant

Of the 204 primary meta-analyses performed, nominally significant associations ( P < 0.05) with the risk of sepsis were found with 26 (34%) variants of 21 genes for at least one genetic model containing TLR1 rs5743551-7202A/G; LBP rs2232618 Phe436Leu; the MBL2 A/O haplotype; RAGE rs1800625-429 T/C and rs1800624-374 T/A; NOD2 rs2066844 Arg702Trp and rs2066847 Leu1

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.