A Randomized Clinical Trial of Synbiotics in Irritable Bowel Syndrome: Dose-Dependent Effects on Gastrointestinal Symptoms and Fatigue.

Korean J Fam Med · 2019 · PMC6351792 · PMID 30360032

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showed a trendno p-value reported

In addition, the mean changes in abdominal discomfort, abdominal bloating, frequency of formed stool, fatigue VAS, and MFI scores showed a trend toward a dose-response relationship.

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